Diastereoselective, Three-Component Cascade Synthesis of Tetrahydrofurans and Tetrahydropyrans Employing the Tandem Mukaiyama Aldol−Lactonization Process
نویسندگان
چکیده
منابع مشابه
Visible light-induced difunctionalization of electron-enriched styrenes: synthesis of tetrahydrofurans and tetrahydropyrans.
The difunctionalization of electron-enriched styrenes for the synthesis of substituted tetrahydrofurans and tetrahydropyrans in the presence of photoredox catalysts is described. The procedure is highlighted by its operational simplicity, low catalyst loadings (1 mol%), excellent stereoselectivity and mild reaction conditions.
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Palladium-catalyzed oxidative cyclization of alkenols provides a convenient entry into cyclic ethers but typically proceeds with little or no diastereoselectivity for cyclization of trisubstituted olefins to form tetrahydrofurans due to the similar energies of competing 5-membered transition-state conformations. Herein, a new variant of this reaction has been developed in which a PdCl2/1,4-benz...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2008
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo801604k